Abstract Many circular RNAs (circRNAs) are produced from back-splicing of exons of precursor mRNAs and are generally co-expressed with cognate linear RNAs.Methods for circRNA-specific knockout are lacking, largely due to sequence overlaps between forms.Here, we use base editors (BEs) for Slide Switches circRNA depletion.By targeting splice sites in
BackgroundTreatment with anti-EGFR antibody has been shown to prolong survival in patients with RAS wild-type metastatic colorectal cancer (mCRC).However, even patients who initially respond to anti-EGFR antibody therapy, almost without exception, develop resistance to the therapy and then fail to respond.Secondary mutations in the mitogen-activate
Kidney failure is caused by a permanent decline in kidney function and requires renal replacement therapy, one of which is Continuous Ambulatory Peritoneal Dialysis (CAPD).This study aimed to determine the relationship between Slide Switches albumin concentrations and sodium and potassium concentrations in CAPD patients.The study was carried out be
TMG In 1925, the working population of Fortaleza revolted against the measures implemented by the British company Light and Power, which operated the public transport service by trams and electric power production.The measures involved tariff increase and changes in the transportation system (first and second class cars and change in schedule).Popu
With the recent emergence of naked-eye 3D return mobile devices, the 3D video-based applications on the mobile terminal are showing great potential.However, the conventional transmission scheme based on separate source coding and channel coding may fail in the broadcast and mobile scenarios due to the drastic changes in wireless channel condition.R